| Pair Name | Shikonin, Erlotinib | ||
| Phytochemical Name | Shikonin (PubChem CID: 479503 ) | ||
| Anticancer drug Name | Erlotinib (PubChem CID: 176870 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Shikonin, Erlotinib | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Down-regulation | Phosphorylation | EGFR | hsa1956 | |
| Down-regulation | Phosphorylation | PLCG1 | hsa5335 | |
| In Vitro Model | U-87MG ATCC | Glioblastoma | Homo sapiens (Human) | CVCL_0022 |
| DK-MG | Glioblastoma | Homo sapiens (Human) | CVCL_1173 | |
| SNB-19 | Astrocytoma | Homo sapiens (Human) | CVCL_0535 | |
| BS153 | Glioblastoma | Homo sapiens (Human) | CVCL_S444 | |
| A-172 | Glioblastoma | Homo sapiens (Human) | CVCL_0131 | |
| T98G | Glioblastoma | Homo sapiens (Human) | CVCL_0556 | |
| U-251MG | Astrocytoma | Homo sapiens (Human) | CVCL_0021 | |
| Result | These results suggest that the combination of erlotinib with shikonin or its derivatives might be a potential strategy to overcome drug resistance to erlotinib. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Shikonin and its derivatives inhibit the epidermal growth factor receptor signaling and synergistically kill glioblastoma cells in combination with erlotinib. Int J Cancer. 2015 Sep 15;137(6):1446-56. doi: 10.1002/ijc.29483. | Click |
